Diagnostics

AGE Reader MU

Non-Invasive Cardiovascular Risk Prediction

Non-invasive cardiovascular & diabetes risk prediction

The AGE Reader provides an immediate cardiovascular risk prediction in 12 seconds. The AGE Reader has been designed for patient friendly diagnosis and allows doctors to practice personalized care and prevent disease (progression). The method is convenient, easy to use and extensively validated.

The point-of-care measurement of AGEs offers great opportunities for multiple purposes. A selection of AGE Reader applications:

AGE Reader mu
The AGE Reader mu combines a high measurement quality standard with an innovative design, at an attractive price level. The AGE Reader mu is a perfect Point-of-Care tool for diabetologists, family doctors and private clinics.

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Technology

The AGE Reader has a light source which illuminates the skin of the forearm. This light will excite fluorescent moieties in the tissue which will emit light of a different wavelength. In the used wavelength band the major contribution in fluorescence comes from fluorescent AGEs linked mostly to collagen, but also to other proteins and lipids. The emitted light is detected using a spectrometer.

By using specific technical adaptations including selection of specific wavelength, modulated or pulsed light sources, a more selective discrimination of specific AGEs is obtained.

The AGE Reader measures tissue accumulation of Advanced Glycation Endproducts (AGEs) by means of fluorescence techniques (skin autofluorescence). AGEs play a key role in the pathogenesis of many age-related diseases, such as diabetes, cardiovascular disease, renal failure and metabolic syndrom. By this, the AGE Reader is a good alternative or additional instrument to traditional risk factors and i.e. the Framingham risk score.

AGE Reader in clinical care

The information of the AGE Reader can assist physicians in focusing treatment on patients with the highest risk of complications. This includes patients suffering from diabetes mellitus, renal failure but also acute disorders like acute coronary syndromes and sepsis.

The non-invasive AGE Reader measurement is in particular of added value to the classic risk factors in predicting the cardiovascular risk of diabetes patients. The AGE Reader measurement reflects the glycometabolic memory which is not covered by the classic risk markers and has been shown to add clinically relevant information to the cardiovascular risk prediction for diabetes patients.

In diabetes patients the AGE Reader has been shown to:

  • Reflect the vascular damage of a patient.
  • Identify diabetes patients at risk of developing cardiovascular complications.
  • Identify diabetes patients at risk of developing microvascular complications.
  • Be a cost-effective assessment tool that adds clinical value to conventional risk engines.

The information of the AGE Reader measurement can be especially interesting for the following applications:

  • Measurement results serves as a motivation tool for patients.
  • Assist in clinical decision making about intensifying or changing treatment of diabetes patients, such as switching to more intensive diabetes treatments or multiple therapy.
  • Assist in clinical decision making about the cut-off levels for classic cardiovascular risk markers.
  • Identify patients with an increased risk of developing complications which were not identified based on the classic cardiovascular risk markers.

The AGE Reader is already being sold internationally since 2006. You can find experiences of our customers on using the AGE Reader in diabetes care here.

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